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NFL: Philadelphia Eagles vs San Francisco 49ers Predictions & Best Bets

Eagles vs 49ers

The Philadelphia Eagles demonstrated their resilience in Sunday’s thrilling overtime victory against the Buffalo Bills.

For the second consecutive week, they conjured late-game heroics to clinch another key win during what has been their most challenging series of games this season.

They now face the San Francisco 49ers, who are riding a three-game winning streak with an impressive average victory margin of 20.6 points.

This is a rematch of the NFC championship game, where the Eagles’ Haason Reddick played a pivotal role in knocking 49ers quarterback Brock Purdy out early, leading to fourth-stringer Josh Johnson stepping in. The Eagles emerged victorious, advancing to Super Bowl LVII.

Despite their strong 10-1 record, the Eagles find themselves in the unusual position of being the underdogs for Sunday’s game at Lincoln Financial Field, facing a formidable 8-3 49ers team.

We’ve put together our best bets based on the latest NFL betting odds. If you’re looking to enhance your experience with NetBet Sport, you can benefit from boosted 1×2 odds on the biggest sporting events with BetPlus.

Eagles vs 49ers Matchup

The San Francisco 49ers have been impressive this season on both offence and defence, averaging 28.2 points and 250.1 passing yards per game, with 19 passing touchdowns and six interceptions.

Their running game is strong too, averaging 136.0 yards with 18 touchdowns while on the other side of the ball, they’ve allowed only 15.5 points per game and five rushing touchdowns.

In their last game against the Seahawks, they led 24-3 at halftime and won 31-13. Brock Purdy threw for 209 yards, and Christian McCaffrey had 114 rushing yards with two touchdowns as Deebo Samuel contributed with seven catches for 79 yards.

The Philadelphia Eagles are also performing well, averaging 28.2 points per game and allowing 22.4 points defensively.

They generate 231.0 passing yards per game, with 18 touchdowns and 10 interceptions, and their running game averages 133.3 yards per game with 17 touchdowns.

In their recent game against Buffalo, the Eagles rallied with 17 points in the fourth quarter to force overtime, eventually winning 37-34.

Jalen Hurts passed for 200 yards and three touchdowns, D’Andre Swift ran for 80 yards, and DeVonta Smith had seven receptions for 106 yards and a touchdown.

Eagles vs 49ers Prediction

Philadelphia, following their narrow win over Buffalo, will be looking to be a little more convincing here.

The Eagles’ defence allowed the Bills 505 total yards and 29 first downs, with Buffalo converting 13 of 22 third-down attempts.

Philadelphia’s offense did just enough, gaining 378 yards with 193 passing yards and 24 first downs.

However, their recent trend of winning close games by seven points or fewer, despite facing strong opponents, indicates they might be taking risks.

In contrast, the 49ers showcased a robust defence against the Seahawks, limiting them to only 220 yards and 14 first downs.

Offensively, San Francisco has been on a roll, scoring 27 or more points in each game of their three-game winning streak and this offensive momentum could pose challenges for Philadelphia.

While the Eagles are expected to have the edge at home, the 49ers’ recent form suggests they could give Philadelphia a tough game.

It’s set to be an engaging matchup, with both teams bringing strengths and vulnerabilities into play.

Best NFL Bets for Eagles vs 49ers

Eagles +2.5 @ 1.95

Philadelphia finds themselves in an unusual position. For only the second time this season, and the first time at home since 2021, the Eagles are not the favourites.

The 49ers, on a winning streak with three consecutive victories, have been formidable. They stand out as one of only two teams in the league ranked in the top 5 for both offense and defence. Additionally, their point differential of plus-140 is the second-best in the NFL.

Despite the 49ers regaining full health, the opportunity to back the Eagles as underdogs on their home turf presents a scenario too compelling to overlook.

49ers Over 2.5 TDs @ 1.74

Since their Week 9 bye, the 49ers’ offence has been on a tear, averaging 30.6 points in the past three weeks, a surge that aligns with the return of Samuel and Trent Williams from their injuries.

Their next challenge is a Philadelphia secondary that has shown vulnerability to explosive plays.

The Eagles have conceded over 30 points in three games and currently sit 19th in the NFL in terms of average yards allowed, at 341 per game.

So, it’s reasonable to expect a game with plenty of scoring, not least from this potent San Francisco offensive line.

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