Liverpool begin their quest for another Champions League title with a match against Atletico Madrid at Anfield.
And Reds boss Arne Slot has confirmed that Premier League record signing Alexander Isak could play a limited role in the clash after missing pre-season.
Below, we preview Liverpool’s latest meeting with Atletico Madrid, providing you with online betting tips and the latest Champions League odds.
And you can earn a £5 Free Bet this week when you place a qualifying £10 Bet Builder on the Champions League match of your choice thanks to our latest Champions League Offer.
Liverpool vs Atletico Madrid Preview
Liverpool have flattered to deceive at the start of the season, but still sit top of the Premier League table with four wins from four.
Victories over Bournemouth, Newcastle, Arsenal and Burnley – all of them courtesy of late goals – mean the mood on Merseyside remains as positive as ever.
And this match represents the perfect opportunity for Liverpool’s new signings to strut their stuff on the biggest stage.
Playmaker Florian Wirtz is yet to record a goal contribution in a Reds jersey, but scored six times in nine Champions League appearances for Bayer Leverkusen last season.
As for Hugo Ekitike, this will be only his fifth appearance in the competition, but he has started the campaign well under Slot with three goals in five appearances.
And the prospect of seeing Isak in action for the first time will only add to the atmosphere at Anfield ahead of kick-off.
Atletico have started the season in poor fashion, but did manage to pick up a first La Liga win of the campaign on the weekend, beating Villarreal 2-0 at the Wanda Metropolitano.
Prior to that, Diego Simeone’s side had lost 2-1 to Espanyol and drew 1-1 with both Elche and Alaves.
So there are clear weaknesses at the back for Atletico, which is rare during the Simeone era. Furthermore, key striker Julian Alvarez will miss the match at Anfield through injury, which represents another blow.
But the Argentine boss has other attacking stars to rely on in Antoine Griezmann and Alexander Sorloth, who will look to target a Liverpool defence in a period of transition after bringing in new faces over the summer in Jeremie Frimpong and Milos Kerkez.
These two sides last met in the Champions League back in the 2021 group stage, with the Reds claiming a deserved 2-0 win at Anfield.
Liverpool vs Atletico Madrid Odds
*All odds are subject to change
Liverpool are the favourites to win this one at a price of 1.56. A victory for Atletico is at long odds of 5.20, while the draw is 4.30.
Liverpool vs Atletico Madrid Betting Tips
Player to score or assist – Mohamed Salah @ 1.57
The odds here are not the best, but wagering on Salah to score or assist in a match at Anfield is always a sensible course of action. The Egyptian netted a stoppage-time penalty to seal the 1-0 win at Burnley last Sunday. He also scored three goals and tallied four assists from nine appearances in the Champions League last season.
Atletico Madrid to score over 0.5 goals @ 1.47
Liverpool’s defence does not look overly solid right now, with Kerkez struggling a bit at left-back and Frimpong yet to really feature at right-back due to injury. Even with Virgil van Dijk marshalling the back-line, we feel confident that Atletico will grab at least one goal, a feat they have achieved in every match so far in 2025-26.
Liverpool to win and over 2.5 goals in the match @ 2.15
And if you agree with our tip above, this could be a great selection at increased odds. Liverpool have conceded at least once in five of their last six competitive matches at Anfield.
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