The 2025-26 Premier League roadshow continues with another midweek slot.
This week’s fixtures mark the end of the busy festive period in the English top flight, with the table really beginning to take shape.
With 10 amazing games to look forward to across Tuesday, Wednesday and Thursday, here are our picks for Matchday 21 based on NetBet’s latest offering of Premier League odds.
And if you wish to place a combo bet on the upcoming football action, our Acca Boost feature helps you play by increasing your potential winnings by up to 50%.
*All odds are subject to change
Everton vs Wolves: To assist a goal double chance – Jack Grealish OR James Garner @ 2.75
Everton were beaten 4-2 by Brentford on the weekend, and David Moyes will be looking for a response against rock-bottom Wolves. There were few positives to take from the loss to the Bees, though Grealish’s two assists was perhaps one of them. The fleet-footed forward has really caught the eye on Merseyside this season, and his team-mate Garner has also registered two assists in 2025-26 top-flight action. Against a team without a win on the road, betting on one of the two Englishmen to flex their creative muscles once again feels like a good move to make. Grealish tallied two of his six Premier League assists in Everton’s 3-2 win at Molineux back in August.
Aston Villa to beat Crystal Palace @ 2.31
Villa bounced back from a 4-1 loss at Arsenal in superb fashion, beating Nottingham Forest 3-1 at home. Unai Emery’s men will therefore be fairly confident ahead of a trip to struggling Palace, who are now five without a win in the top flight following the 2-0 loss at Newcastle. Fatigue appears to be impacting Oliver Glasner’s side, and new signing Brennan Johnson could not provide any sort of spark at St James’ Park. Prior to the loss at the Emirates, Villa had won five consecutive away matches across all competitions, and we fancy them to get back to business on the road at Selhurst Park – and exact revenge for Palace’s 3-0 win at Villa Park in August!
Brentford vs Sunderland: Anytime goalscorer – Igor Thiago @ 2.10
After a few quiet weeks, Thiago exploded into life at the Hill Dickinson Stadium, sinking Everton with a magnificent hat-trick. The striker is now up to 14 goals for the season, just one short of equalling the record for a Brazilian in a single Premier League campaign. Of course, Sunderland represent a stern test, although the Black Cats have been far better at home than on the road. Regis Le Bris’ side have won only two of 10 away fixtures in 2025-26, and Brentford are currently fourth in the division’s home table. With Thiago also on penalty duty, this contest looks tailor-made for a record-equalling strike from the Bees’ talisman.
Bournemouth to beat Tottenham @ 2.10
Bournemouth suffered only a second home loss of the season last Saturday, with Arsenal winning 3-2 at the Vitality Stadium. But it was still a top performance from Andoni Iraola’s side, one packed full of energy and guile. If the Cherries can repeat that display against struggling Spurs, you have to fancy them to pick up the victory. Spurs mustered only a 1-1 draw with Sunderland last time out, and have recorded just one top-flight win in the previous five. Bournemouth won this fixture 1-0 last season, and repeated that feat in North London earlier in the campaign.
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